Scientists link this incredibly popular class of drugs with an 18% lower risk of Alzheimer’s | Top Vip News


Erectile Dysfunction Drugs Viagra

A recent study indicates a potential link between erectile dysfunction medications and a lower risk of developing Alzheimer’s disease, showing an 18 percent risk reduction among users after adjusting for several factors. While promising, the findings underscore the need for more research to explore the underlying mechanisms and benefits, and whether these results apply to women.

According to new research published in Neurologythe medical journal of the American Academy of Neurology, medications to treat erectile dysfunction may also be linked to a lower risk of Alzheimer’s disease. However, the study indicates a correlation rather than proving that ED medications directly decrease the risk of Alzheimer’s disease.

Erectile dysfunction drugs, which work by dilating blood vessels to allow more blood to flow, were first developed to treat high blood pressure. A new study suggests the medications may be linked to a reduced risk of Alzheimer’s disease.

“Although we are making progress with new treatments for Alzheimer’s disease that work to remove amyloid plaques in the brains of people with early stages of the disease, we desperately need treatments that can prevent or delay the development of Alzheimer’s disease,” he said. the study. author Ruth Brauer, Ph.D., of University College London in the United Kingdom. “These results are encouraging and warrant further investigation.”

Study details

The study involved 269,725 male participants with an average age of 59 who were recently diagnosed with erectile dysfunction. The participants did not have any memory or thinking problems at the beginning of the study. They were then followed for an average of five years. The study compared 55% of participants who had prescriptions for ED medications with 45% who did not have prescriptions.

During the study, 1,119 people developed Alzheimer’s disease.

Among participants taking ED medications, 749 developed Alzheimer’s disease, corresponding to a rate of 8.1 cases per 10,000 person-years. Person-years represent both the number of people in the study and the amount of time each person spends in the study. Among those who did not take the medications, 370 developed Alzheimer’s disease, corresponding to a rate of 9.7 cases per 10,000 person-years.

Once the researchers adjusted for other factors that could affect the rate of Alzheimer’s disease, such as age, smoking and alcohol consumption, they found that people taking ED medications were 18% less likely to develop Alzheimer’s than people who did not take the medications. drugs.

The association was stronger in those who were issued more prescriptions during the study period.

Future research directions

“More research is needed to confirm these findings, learn more about the possible benefits and mechanisms of these drugs, and analyze the optimal dosage,” Brauer said. “A randomized controlled trial with male and female participants is warranted to determine whether these findings would also apply to women.”

Reference: “Phosphodiesterase type 5 inhibitors in men with erectile dysfunction and risk of Alzheimer’s disease: a cohort study” by Matthew Adesuyan, Yogini H. Jani, Dana Alsugeir, Robert Howard, Chengsheng Ju, Li Wei and Ruth Brauer, February 7, 2024, Neurology.
DOI: 10.1212/WNL.0000000000209131

The study was based on prescription records. One limitation of the study is that the researchers did not have information about whether the participants actually filled the prescriptions and used the medications.

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