Study identifies key genes for Parkinson’s disease in young people | Top Vip News

A new study by MedGenome, a genomics-based research and diagnostics company, in association with the Parkinson’s Research Alliance of India (PRAI), has found that rare genetic variations along with common risk score-derived variants polygenic (PRS) can detect young onset. of Parkinson’s Disease (YOPD).

The study, published in Movement Disorders, the official journal of the International Parkinson and Movement Disorders Society, has validated existing knowledge about the disease along with new findings on the genetics of Parkinson’s disease.

According to a company press release, a pilot study through collaboration with PRAI was published in the July 2022 issue of Advanced Biology, a peer-reviewed interdisciplinary biology journal with 100 complete genomes from patients with Parkinson’s disease.

This is the first study of its kind conducted in India with the aim of initiating a population genetic analysis of YOPD in the Indian population. Genetics of PAN-India Young Onset Parkinson Disease (GOPI-YOPD), a Pan India multi-centre project, recruited 674 patients across a network of 10 movement disorders centres/neurology clinics across India over a period of two years.

genetic mutations

The study validates existing findings in European populations and identifies important genetic mutations in genes, which are not observed in other populations. The study aggregates common genetic variations into a polygenic risk score (PD-PRS), introducing a genetic screening test to assess the risk of developing Parkinson’s disease, according to the release.

“This comprehensive analysis of rare and common genetic variations in YOPD in the Indian population improves the understanding of the genetic basis of Parkinson’s disease and introduces a new genetic screening approach to assess disease risk,” the statement said.

Genomic analysis for the study was performed at MedGenome Labs using MedGenome’s SARGAM (South Asian Research Genotyping Array for Medicine), which has curated content from a proprietary database of 2.5 million variants unique to the southern population. from Asia that is not publicly available. genetic database available.

neurological disorder

One of the authors, Rupam Borgohain, Secretary, PRAI and Chairman, Parkinson’s Disease and Movement Disorders Research Center (PDMDRC), Citi Neuro Centre, Hyderabad, said: “Parkinson’s disease is a common neurological disorder that causes tremors, slowness of movement, stiffness, and difficulty walking.” in the majority. It is caused by a complex interaction between external environmental and family or genetic factors.

“Based on the initiative of Prashanth LK, specialist in movement disorders, Parkinson’s disease and movement disorders clinic in Bengaluru, the first of its kind pan-India registry on young-onset Parkinson’s disease (disease that begins before age 50). PRAI… Parkinson’s disease with onset before age 20 (juvenile PD), between 20 and 40 years (young-onset PD), and between 40 and 50 years (early-onset PD) has different clinical characteristics. The role of genetic factors appears to be greater in these patients compared to advanced age,” said Professor Borgohain.